Advancing PCR testing for SARS-CoV-2 (Finn): Working to establish quantitative real time polymerase chain reaction (PCR) tests which enable scientists to look for the genetic sequences specific to the virus and show if someone is infected at the time of testing. Funder: Elizabeth Blackwell Institute (£4,980.00).
A mixed-methods evaluation of advice on isolation and health-seeking to contain transmission (Oliver, Lambert, Hickman, Yardley, Amlôt, Rubin, James, Zhang, Lasseter): Mixed methods assessment of advice to self-isolate or social distance in terms of its acceptability, adherence and impact on health and wellbeing. Funder: UKRI (£400,000). with NIHR HPRU in Emergency Preparedness and Response at King's College London. Start-End dates: 30/3/2020-29/09/2021.
Bristol UNCOVER (Bristol COVID Emergency Research) Group (Led by Adam Finn and includes various other researchers): A group of Bristol researchers united to collaborate on finding ways to overcome the disease. Funder: N/A. Ongoing
Conduct of rapid reviews relating to mental health and psychosocial support (Weston, Amlôt): Rapid evidence reviews relating to mental health and psychosocial support in the context of COVID-19. Funder: PHE and in partnership with NIHR HPRU in Emergency Preparedness and Response at King's College London. Start-End dates: March 2020 onwards.
COVID-19 in Older People: A Rapid Clinical Review (Lithander, Christensen) : Rapid review of clinical aspects of COVID-19 with a focus on older people. Lead: Fiona Lithander. Co-Investigator(s): Hannah Christensen [co-author, et al]. Funder: N/A. Start-End dates: 23/03/2020 - 17/04/2020
Contact patterns and behaviour in University of Bristol Staff and students during the COVID-19 pandemic (Emily Nixon, Ellen Brooks-Pollock, Leon Danon, Hannah Christensen, Adam Finn, Adam Trickey, Amy Thomas, Jane Metz and others). Funder: Elizabeth Blackwell Institute
Developing polling methods to support the response to COVID-19 (Amlôt co-I): Survey to assess people’s behavioural responses to the pandemic. Funder: NIHR Policy Research Programme (£150k). Start-End dates: February 2020 ongoing.
Epidemiology and transmission of COVID-19 in cases and close contacts in Georgia
(Walker, Vickerman, Lim, Trickey, Stone). Funder: Elizabeth Blackwell Institute (£11,148)
Evaluation of large scale population testing programme for anti-SARS-CoV-2 antibody using “pregnancy test-like” lateral immunochromatography home test kits (Oliver)
Evaluation of the PHE contact tracing programme during the contain phase (Oliver)
Experiences of people who inject drugs during the COVID-19 pandemic (Hines, Kesten, Horwood, Telfer, Ayres). Funder: Elizabeth Blackwell Institute (£2,484). Start/end date: May 2020-August 2020.
Healthcare seeking behaviour and contact patterns during the COVID-19 pandemic: informing predictive modelling (Brooks-Pollock). Funder: UKRI
Impact of COVID-19 outbreak on selected conditions (non-respiratory conditions and non-GI infections) using PHE real-time syndromic surveillance system data in England (Oliver) in collaboration with NIHR HPRU in Emergency Preparedness and Response at Kings College London
Impact of social distancing advice during the containment and delay phases of Covid-19 (Spottiswoode, Kenward, Robin, Oliver, Hickman): PHE are evaluating the effectiveness, acceptability and impact of advice to “shield” in a sample of 300 clinically vulnerable people in the South West.
Implementation of a digital behavioural change intervention to improve hand hygiene (Yardley, et al): evaluation in UK and China of how ‘Germ Defence’ (www.germdefence.org) can be rapidly adapted and optimised for the COVID-19 outbreak, using novel participatory-co-design methods. Funder: UKRI (£200,000).
Interoperability during COVID-19 response (Carter lead supervisor, Amlôt co-supervisor): Collaboration with Keele University to understand the ongoing challenges faced by responders as part of the Civil Contingency Response to COVID-19, particularly as these relate to interoperability. Funder: in partnership with NIHR HPRU in Emergency Preparedness and Response at Kings College London. Start-End dates: January 2020 - November 2020.
LOGIC study (Longitudinal study of COVID-19: Symptoms, Virology & Immunology) (Finn, Goenka): Longitudinal collection of respiratory and blood samples, as well as symptom diaries, from frontline healthcare workers in the emergency department of Bristol Royal Hospital for Children. Funder: Grand Appeal (£58,513.00).
Mass antibody testing programme evaluation (Oliver, Mulchandani, Wyllie, Jones, Charlett, Hickman, Brooks, Taylor-Phillips, Albrow, Ades, Walker): Evaluate point of care (POC) antibody test kits to assess accuracy in the population, and understand the usability and feasibility of the home-based roll out of the programme.
Mental health screening for NHS staff (Weston, Amlôt): Working with NHSE/I to develop an online mental health screening tool which can be used by frontline NHS staff. Collecting anonymous information from up to 1.5M staff and provide feedback about their mental health and where to seek appropriate help. Funder: In partnership with NIHR HPRU in Emergency Preparedness and Response at Kings College London. Start-End dates: April 2020 onwards.
RAPCI Project: Rapid COVID-19 Intelligence to improve primary care response (Murphy, Horwood, Salisbury, MacLeod, Denholm). Funder: NIHR School for Primary Care Research (£40,000.00) Start-End dates: 04/01/2020 - 31/08/2020
Rapid Covid-19 evidence summaries (Horwood): A group of Bristol researchers (including HPRU BSE staff) are reviewing evidence to help inform decision-making and to support strategic responses to COVID-19 (https://arc-w.nihr.ac.uk/research-and-implementation/covid-19-response).
Rapid evaluation of the effectiveness of public health information materials on COVID-2019 provided to passengers arriving at UK airports from China (Oliver, Lambert, PHE colleagues plus HPRUs in BSE and EPR): Evaluation of PHE English and Chinese leaflets and posters about Covid-19 provided to incoming passengers. Funder: Department of Health and Social Care (DHSC) (£20,000). Start-End dates: 03/02/2020-30/02/2020
Real-time mathematical modelling of COVID-19 in SW England (Booton, Turner, MacGregor, Danon, Brooks-Pollock, Wood): Develop a new model of COVID transmission focussing on demand for hospital beds, which can be used with local/regional or national data. Leads: Funder: Elizabeth Blackwell Institute (£400 + publication fees). Start-End dates: 01/04/2020 - 31/07/2020
Social contacts and mixing patterns under COVID19 social distancing measures (Christensen): Estimating social contacts and mixing patterns in older people under the current social distancing policies in place to address COVID19. Funder: Elizabeth Blackwell Institute (EBI) £3,350.00. Start-End dates: 27/04/2020 to 31/05/2020
Social identity, social support and social distancing (Carter, Weston, Amlôt): Longitudinal survey to examine: the impact of social identity and social support on mental and physical health outcomes during social distancing, and whether the content of social identities changes as a result of social distancing. Funder: In partnership with NIHR HPRU in Emergency Preparedness and Response at Kings College London. Start-End dates: April 2020 onwards.
The effects of school closures on children and parents (Amlôt co-supervisor): A PhD project (amended) to understand how children and parents are currently coping during the pandemic. Funder: ESRC Case Studentship and in partnership with NIHR HPRU in Emergency Preparedness and Response at Kings College London. Start-End dates: March 2020 onwards.
The impact of contact tracing on contact tracers (Oliver): Survey.
The impact of epidemic outbreaks on the mental health of pregnant women (Brooks, Weston, Greenberg). Rapid evidence review to explore the psychological impact of being pregnant during an infectious disease outbreak.
The impact of school closures on interactions among children (Brooks, Smith, Webster, Weston, Woodland, Hall, and Rubin): Rapid evidence review of previous studies on school closure. This report was cited by the modelling subgroup of SAGE in their considerations around school closure. Publication: Eurosurveillance 2020; 25:13.
To understand and evaluate the impact of the COVID-19 outbreak on GI infections in England in collaboration (Oliver) with NIHR HPRU in Gastrointestinal Infections at University of Liverpool
UKRI Transmission and Mathematical Modelling (Presanis, De Angelis, Tom, Charlett, Birrell): Using Bayesian statistical models to combine multiple datasets to understand the severity of the epidemic – such as the proportion of infections that result in hospitalisation or death. Funder: UKRI/MRC/NIHR (£200,000). Start-End dates: 01/04/2020 - 30/09/2021
UKRI Transmission and Mathematical Modelling (Danon, Brooks-Pollock, Finn): Adapt and develop mathematical models of disease spread and movement within the UK to evaluate the impact of control and mitigation strategies, and to predict where and when the disease will spread. Funder: UKRI (£200,000).
Understanding the immuno-modulatory effects of BCG on subsequent exposure to SARS-CoV2 in human mucosal cells using air liquid interface models (Hill, Davidson, Goenka, Finn). Funder: Elizabeth Blackwell Institute (£4,606).
Understanding the impact on, and experiences of, young people during the COVID-19 pandemic (Fisher, Audrey, Hickman, Yardley, Lambert): Qualitative work to understand the impact on, and experiences of, young people during the coronavirus (COVID-19) pandemic. Funder: Elizabeth Blackwell Institute (£4,626). Start-End dates: 01/05/2020 - 31/12/2020
Use of digital technologies and self-reported loneliness by older individuals self-isolating during COVID-19 (Lasseter, Christensen, Grant, Sauchelli Toran). Funder: Elizabeth Blackwell Institute
Using linked primary care and viral surveillance data to develop risk stratification models to inform management of severe COVID-19 (Payne, Kontopantelis, Mant, Denholm, Cooper, Forbes, Herbert, Tammes). Funder: NIHR School for Primary Care Research. Start-End Dates: 20/04/2020 - 20/10/2020